Formulation and Evaluation of Avocado Leaf Extract (Persea americana Mill.) Cream Based on Variations Stearic Acid Concentration


  • Bahariyan Ramdhan PAFI Kota Banjar
  • Anna L Yusuf STIKes Muhammadiyah Ciamis



Formulation, cream, Stearic Acid, Avocado Leaf Extract.


Avocado leaves (Persea americana Mill.) contain flavonoid compounds as high as 8.11 mg, so they have potential in the acne healing process. The aim of this research is to create a formulation and evaluate an avocado leaf extract cream preparation. The method used is experimental. Avocado leaf extract cream preparations are made based on varying stearic acid concentrations of 5%, 10% and 15%. Evaluation of the preparation includes organoleptic tests, homogeneity tests, pH tests, spreadability tests, adhesion tests, and viscosity tests. Based on the organoleptic evaluation, the results showed that FI was slightly runny and contained bubbles, FII was slightly thick and FIII was thick. The FI color is brownish white, FII is yellowish white, and FIII is white, and all formulations have a characteristic creamy odor. The homogeneity test shows that all formulas have the same homogeneous preparation. The pH test of the cream preparation showed the same pH value, namely 6. The spreadability test resulted in good spreadability of the cream, namely between 5 and 6.8 cm. The cream adhesion test has an adhesion between 00.53 and 1.38 seconds. And finally, the viscosity test has a viscosity value between 4500 and 8900 mpa. According to the results of this research, avocado leaf extract cream can be used as a cream preparation, with the best stearic acid concentration being 15%.


Anwar, E. 2012. Excipients in Pharmaceutical Preparations (Characterization and Application). Dian Rakyat. Jakarta.

A. P. Juwita and E. Yamlean, Paulina V Y. 2013. Extract Cream Formulation Seagrass Leaf Ethanol (Syringodium isoetifolium), vol. 2, no. 02, pp. 8–13.

Avish D Maru, Swaroop R Lahoti. 2018. Formulation and Evaluation of Moisturizing Cream Containing Sunflower Wax. International Journal Of Pharmacy and Pharmaceitical Science. ISSN:0975-1941 Vol.10 Issue.11

De Oliveira A, Franco E, Rodrigues Barreto R, Cordeiro D, de Melo R, De Aquino C et al. Effect of Semisolid Formulation of Persea Americana Mill (Avocado) Oil on Wound Healing in Rats. Evidence-Based Complementary and Alternative Medicine. 2013; 1-8.

Depkes RI. 2006. Monograph on Indonesian Medicinal Plant Extracts, Vol.2. Jakarta: Republic of Indonesia Ministry of Health.

Dina Mailana, Nuryanti. 2016. “Extract Antioxidant Cream Formulation Avocado Leaf Ethanol (Persea americana Mill.),” vol. 4, no. September, pp. 7–15, 2016.

Ikhsanudin. A., “Formulasi Vanishing Cream Minyak Atsiri Rimpang Jahe (Zingiber officinale Roxb) Dan Uji Aktivitas Rapelan Terhadap Nyamuk Aedes aegypti Betina,” J. Ilm. Kefarmasian, vol. Vol. 2, pp. 175–186, 2012.

Ramadan M. Fruit Oils: Chemistry and Functionality. Switzerland: Springer Nature Switzerland AG. 2019;353-375.

Yuliani, wulan, Ismail, Rian. 2023. Uji Aktivitas Antijamur Fungi Endofit Tanaman Sarang Semut (Myrmecodia pendans) Terhadap Jamur Candida albicans. Pharmacy Genius. P:31-42.

Sunil Ranade S, Thiagarajan P. 2015. A Review on Persea Americana Mill. (Avocado) - Its Fruit and Oil. International J of PharmTech Research. 8(6):72-77.

Segovia F, Hidalgo G, Villasante J, Ramis X, Almajano M. 2018. Avocado Seed: A Comparative Study of Antioxidant Content and Capacity in Protecting Oil Models from Oxidation. Molecules. 23(10):2421.

Sry Wardiyah. 2015. Comparison of the physical properties of cream, gel and ointment preparations containing ethyl p-methoxycinnamate from galangal rhizome extract ( kaempferia galanga Linn.).

Tri Setiawan. 2010. Physical Stability Test and Determination of the SPF Value of Screen Cream Surya Contains Green Tea Leaf Extract (Camellia sinensis L.), Octyl Methoxycinnamate and Titanium Dioxide.

Widodo. H. 2013. The Science of Dispensing Medicines for Pharmacists, 1st Edition, D-Medika Publisher, Yogyakarta.




How to Cite

Ramdhan, B., & Yusuf, A. L. (2023). Formulation and Evaluation of Avocado Leaf Extract (Persea americana Mill.) Cream Based on Variations Stearic Acid Concentration. Ad-Dawaa : Journal of Pharmacy, 1(2), 78–86.