Ad-Dawaa : Journal of Pharmacy

Susceptibility Test of Aedes aegypti Larvae to Temefos (Abate)

Tuti Maula Fauziah — 2023-11-30

Dengue fever is an infectious disease transmitted by the Aedes aegypti mosquito. Temefos is a tool used in controlling Aedes aegypti larvae and its use for a long time without based on rules can cause resistance. This study aims to determine the susceptibility status of Aedes aegypti larvae to Temefos in the Ciamis and Cimaragas areas. The method of this research is experimental with samples obtained from residential areas in Ciamis and Cimaragas sub-districts then hatched into instar IV larvae at the Parasitology Laboratory of STIKes Muhamamadiyah Ciamis in May 2019. The results of the test on temefos 0.1 g showed that Aedes aegypti larvae from both regions obtained the results of Ciamis (100%) and Cimaragas (100%) sub-districts were still susceptible to temefos. From these results it can be concluded that the test larvae from both areas are still susceptible to temefos so that the tool can still be used as a larvicide, especially in controlling Aedes aegypti mosquitoes.

Formulation and Evaluation of Avocado Leaf Extract (Persea americana Mill.) Cream Based on Variations Stearic Acid Concentration

Bahariyan Ramdhan — 2023-11-30

Avocado leaves (Persea americana Mill.) contain flavonoid compounds as high as 8.11 mg, so they have potential in the acne healing process. The aim of this research is to create a formulation and evaluate an avocado leaf extract cream preparation. The method used is experimental. Avocado leaf extract cream preparations are made based on varying stearic acid concentrations of 5%, 10% and 15%. Evaluation of the preparation includes organoleptic tests, homogeneity tests, pH tests, spreadability tests, adhesion tests, and viscosity tests. Based on the organoleptic evaluation, the results showed that FI was slightly runny and contained bubbles, FII was slightly thick and FIII was thick. The FI color is brownish white, FII is yellowish white, and FIII is white, and all formulations have a characteristic creamy odor. The homogeneity test shows that all formulas have the same homogeneous preparation. The pH test of the cream preparation showed the same pH value, namely 6. The spreadability test resulted in good spreadability of the cream, namely between 5 and 6.8 cm. The cream adhesion test has an adhesion between 00.53 and 1.38 seconds. And finally, the viscosity test has a viscosity value between 4500 and 8900 mpa. According to the results of this research, avocado leaf extract cream can be used as a cream preparation, with the best stearic acid concentration being 15%.

Phytochemical Analysis of Flavonoids and Tannins from Ethanol Extract of Keji Beling (Strobilanthes crispus) Using UV-Vis Spectrophotometry Method

Ayu Safitri — 2023-11-30

Keji Beling (Strobilanthes crispus BI.) is a plant that has been used by the community as a traditional medicine for kidney stones, diabetes mellitus, ulcers and as a laxative. Keji beling contains many beneficial substances such as flafonoids and tannins. This research aims to determine the content of flavonoid and tannin phytochemical compounds and to determine length Maximum waves in flavonoid and tannin compounds in keji beling leaf extract (Strobilanthes crispus BI.). Keji beling leaves were extracted using the maceration method with 70% ethanol solvent. Secondary metabolite content was identified qualitatively using a phytochemical screening test. Flavonoids were tested with concentrated MgSO₄ and HCl reagents and tannins were tested with FeCl3 reagent. Qualitative analysis using the UV-Vis Spectrophotometry method. Results Research shows that the phytochemical screening test on keji beling leaf extract (Strobilanthes crispus BI.) is positive for containing flavonoids and tannins, indicated by a color change in the phytochemical screening test. Qualitative analysis results appear at a maximum wavelength of 465 nm for flavonoids, and for tannin compounds at a maximum wavelength of 765 nm.

Determination of Vitamin C Levels in Limes (Citrus aurantifolia Swingle) and Lemon (Citrus limon (L.) Burm. f.) Using the UV Vis Spectrophotometric Method

Gita Rizkasari — 2023-11-30

Vitamin C or ascorbic acid is one of the vitamins needed by the body which functions to help the body's metabolic processes and plays a role in the formation of intercellular collagen. The source of vitamin C in food mostly comes from fresh vegetables and fruit. Limes and lemons are plants that contain vitamin C and have many benefits for the body. This research The aim was to determine the levels of vitamin C in limes (Citrus aurantifolia) and lemon (Citrus Limon) are planted in the area Situmandala Rancah District using UV-Vis Spectrophotometry at a wavelength of 400-600 nm. The samples for this research were limes and lemons. The results of this research showed that the vitamin C level in limes was 0.218% and in lemons it was 0.816%.

Evaluation of Waiting Time Prescription Services in Hospital Pharmacy Installations in the Tasikmalaya Area

Nita Asiah — 2023-11-30

Pharmaceutical Services in Hospitals are part which is inseparable from the Home health service Hospital System that is oriented towards patient service, provision pharmaceutical preparations, medical devices and consumable medical materials quality and affordable for all levels of society. The aim of this research is to determine the suitability of the waiting timer for recipe service at Medika Citratama Hospital in Tasikmalaya base on Minister of Health Regulation No.129/Menkes/SK/II/2008, namely the waiting time for concoction 60 minutes and non-concoction waiting time 30 minutes. The research method is descriptive by making observations or observing directly using observation. Data taken were 370 outpatient prescriptions, consisting of 270 non-concocted and 90 concocted prescriptions. The average waiting time for prescription services is 26.30 minutes for non-mixed prescriptions and 52.20 minutes for prescriptions. concoction.

Narrative Review: Optimation of Ethanol as a Solvent for Flavonoid Compounds in Papaya Leaf Extraction

Davit Nugraha — 2023-11-30

Ethanol is widely used as a distiller of secondary metabolite compounds. Ethanol very well dissolves secondary metabolite compounds including flavonoids group compounds including for papaya (Carica papaya L.) leaf extraction. This review was conducted to examine solvent optimization that has been used in various original studies. The method of searching scientific journal article using PubMed and MDPI using keyword “extraction and ethanol and flavonoid and carica papaya leaf” with the inclusion criteria of 2018 – 2023 article, free full text and not review articles, the number of article obtained was 3 articles. The optimal concentration of ethanol as a flavonoid extract solven is 70 % ethanol at temperatures from 30 °C – 50°C with a time range of 10 – 48 hours of immersion.

The Effect Of Increasing Concentrations Of Sodium Saccharin As Sweetener On Physical Properties Of Salbutamol Dispersible Tablet With Mannitol As Filler

Inding Gusmayadi — 2023-11-30

Salbutamol one of asthma medicine which can be made in to dispersible tablet with the addition of sodium saccharin as sweetener. This study aimed to determine effect of increasing concentration of sodium saccharin as sweetener on physical properties and patient acceptabelity of the tablet. The tablet was made into 5 formulas with the 0% of sodium saccharin concentration as Formula 1, 0.2% as Formula 2, 0.4% as Formula 3, 0.6% as Formula 4, and 0.8% as Formula 5. The tablet made by direct compression method. The evaluation of granule including flow time test, angle of repose, and compressibility test. The tablet evaluation including organoleptic, weight uniformity, size uniformity, friability, hardness, wetting time, disintegration time, content uniformity, and hedonic test. The results of the physial properties were the hardness F1 until F5 subsequently 1.70, 1.54, 2.48, 2.67, and 2.73 Kp; the disintegration time F1 until F5 subsquently 55.67, 56.67, 56.67, 57.00, and 58.00 seconds; the friability test 1.09, 1.98, 0.77, 0.65, and 0.63%. The results showed that there were significant differences among all the formulas. It could be concluded that increasing concentration of sodium saccharin as sweetener in salbutamol dispersible tablet increase physical properties and could be made as preferable and acceptable tablet.