KOMBINASI EKSTRAK EKSOKARP BUAH SEMANGKA (Citrullus Lanatus (Thunb.)) DAN EKSTRAK DAUN SALAM (Syzygium Polyanthum) SEBAGAI ANTIKOLESTEROL POTENSIAL PADA MENCIT JANTAN GALUR Balb/C

Abstract

Dyslipidemia is a condition of abnormal lipid profile in the blood such as an increase in total cholesterol, triglycerides (TG), Low-Density Lipoprotein (LDL), and a decrease in High-Density Lipoprotein (HDL) cholesterol. This study aims to compare the effects of watermelon exocarp extract (Citrullus lanatus (Thunb.)) and bay leaf extract (Syzygium polyanthum) and the combination of the two in lowering blood cholesterol levels. This research method was carried out experimentally for 7 days, the data were analyzed using the Paired T-Test, One Way ANOVA (Analysis of Variant), and LSD Post Hoc Test methods with sig = 0.05 to determine the significant difference between the 6 groups. The results of this study indicate the normality test results of cholesterol levels show the value of sig. > 0.05, it can be concluded that the data is normally distributed. In the one-way ANOVA test, it shows sig. <0.05 so it can be concluded that the average of the six test groups differed significantly. The LSD test showed that the treatment of the control group was positive with bay leaf extract, the watermelon fruit exocarp extract group with a combination of bay leaf extract and watermelon exocarp extract which had a sig value. > 0.05 which means there is no significant difference, while the other groups have sig values. <0.05 which means there is a significant difference. The conclusion on the LSD test obtained the value of Sig. > 0.05 which indicates that there is no difference. The greatest decrease in cholesterol levels occurred in the combination group compared to the single group.