Impact of Intermittent Fasting on Genes Involved in Neurodegenerative Diseases

Main Article Content

Rizky Amalia Siregar
Benedikta Diah Saraswati

Abstract

Neurodegenerative diseases, characterized by progressive neuron loss, present a significant global health challenge. Recent research highlights the role of genetic expression in these diseases, with lifestyle interventions, such as dietary changes, shown to influence gene expression linked to neurodegeneration. One promising approach is intermittent fasting (IF), a dietary method alternating fasting and eating periods, which affects biological processes like cellular repair, inflammation, and metabolism. Emerging evidence suggests IF may also alter gene expression related to neurodegenerative diseases, potentially reducing risk and slowing progression. This review examines current studies on the impact of IF on gene expression in neurodegeneration, exploring its mechanisms and implications for new therapeutic and preventive strategies.

Article Details

How to Cite
Siregar, R. A., & Saraswati, B. D. (2025). Impact of Intermittent Fasting on Genes Involved in Neurodegenerative Diseases. JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS, 12(1), 96–104. https://doi.org/10.52221/jurkes.v12i1.817
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References

Andrade-Guerrero, J., Santiago-Balmaseda, A., Jeronimo-Aguilar, P., Vargas-Rodríguez, I., Cadena-Suárez, A. R., Sánchez-Garibay, C., Pozo-Molina, G., Méndez-Catalá, C. F., Cardenas-Aguayo, M. D. C., Diaz-Cintra, S., Pacheco-Herrero, M., Luna-Muñoz, J., & Soto-Rojas, L. O. (2023). Alzheimer’s Disease: An Updated Overview of Its Genetics. International Journal of Molecular Sciences, 24(4), 1–23. https://doi.org/10.3390/ijms24043754

Ayeni, E. A., Aldossary, A. M., Ayejoto, D. A., Gbadegesin, L. A., Alshehri, A. A., Alfassam, H. A., Afewerky, H. K., Almughem, F. A., Bello, S. M., & Tawfik, E. A. (2022). Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities. International Journal of Environmental Research and Public Health, 19(19). https://doi.org/10.3390/ijerph191912495

Cubeles-Juberias, E., Herrero, L., & Romero, M. del M. (2024). Effects of intermittent fasting on metabolism, cognitive function, and aging: a review of human and animal studies. Revista de La Sociedad Española de Cirugía de Obesidad y Metabólica y de La Sociedad Española Para El Estudio de La Obesidad. https://doi.org/10.53435/funj.00924

de Cabo, R., & Mattson, M. P. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. New England Journal of Medicine, 381(26), 2541–2551. https://doi.org/10.1056/nejmra1905136

Diab, R., Dimachkie, L., Zein, O., Dakroub, A., & Eid, A. H. (2024). Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health. Cell Biochemistry and Biophysics, 1583–1597. https://doi.org/10.1007/s12013-024-01314-9

Dong, H., Wang, S., Hu, C., Wang, M., Zhou, T., & Zhou, Y. (2024). Neuroprotective Effects of Intermittent Fasting in the Aging Brain. Annals of Nutrition and Metabolism, 80(4), 175–185. https://doi.org/10.1159/000538782

Funayama, M., Nishioka, K., Li, Y., & Hattori, N. (2023). Molecular genetics of Parkinson’s disease: Contributions and global trends. Journal of Human Genetics, 68(3), 125–130. https://doi.org/10.1038/s10038-022-01058-5

Gadhave, D. G., Sugandhi, V. V., Jha, S. K., Nangare, S. N., Gupta, G., Singh, S. K., Dua, K., Cho, H., Hansbro, P. M., & Paudel, K. R. (2024). Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance. Ageing Research Reviews, 99(May), 102357. https://doi.org/10.1016/j.arr.2024.102357

Gatto, E. M., Rojas, N. G., Persi, G., Etcheverry, J. L., Cesarini, M. E., & Perandones, C. (2020). Huntington disease: Advances in the understanding of its mechanisms. Clinical Parkinsonism and Related Disorders, 3, 100056. https://doi.org/10.1016/j.prdoa.2020.100056

Giri, P. M., Banerjee, A., Ghosal, A., & Layek, B. (2024). Neuroinflammation in Neurodegenerative Disorders: Current Knowledge and Therapeutic Implications. International Journal of Molecular Sciences, 25(7). https://doi.org/10.3390/ijms25073995

Gonzalez Rojas, N., Cesarini, M. E., Peker, G., Da Prat, G. A., Etcheverry, J. L., & Gatto, E. M. (2022). Review of Huntington’s Disease: From Basics to Advances in Diagnosis and Treatment. Journal of Neurology Research, 12(3), 93–113. https://doi.org/10.14740/jnr721

Jeevitha, M., Shanmuga Sundhram, R., & Sambath Kumar, R. (2024). Exploring the Neuroprotective Effects of Intermittent Fasting: A Comprehensive Review on its Impact on Neurological Diseases. Journal of Drug Delivery and Therapeutics, 14(3), 174–178. https://doi.org/10.22270/jddt.v14i3.6486

Kamboh, M. I. (2003). Genetics of Alzheimer’s Disease. Handbook of Medical Psychiatry, 23(4), 521–536. https://doi.org/10.3109/9780203912485-40

Lamptey, R. N. L., Chaulagain, B., Trivedi, R., Gothwal, A., Layek, B., & Singh, J. (2022). A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics. International Journal of Molecular Sciences, 23(3). https://doi.org/10.3390/ijms23031851

Lesage, S., & Trinh, J. (2023). Special Issue “Parkinson’s Disease: Genetics and Pathogenesis.” Genes, 14(3), 6–9. https://doi.org/10.3390/genes14030737

Andrade-Guerrero, J., Santiago-Balmaseda, A., Jeronimo-Aguilar, P., Vargas-Rodríguez, I., Cadena-Suárez, A. R., Sánchez-Garibay, C., Pozo-Molina, G., Méndez-Catalá, C. F., Cardenas-Aguayo, M. D. C., Diaz-Cintra, S., Pacheco-Herrero, M., Luna-Muñoz, J., & Soto-Rojas, L. O. (2023). Alzheimer’s Disease: An Updated Overview of Its Genetics. International Journal of Molecular Sciences, 24(4), 1–23. https://doi.org/10.3390/ijms24043754

Ayeni, E. A., Aldossary, A. M., Ayejoto, D. A., Gbadegesin, L. A., Alshehri, A. A., Alfassam, H. A., Afewerky, H. K., Almughem, F. A., Bello, S. M., & Tawfik, E. A. (2022). Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities. International Journal of Environmental Research and Public Health, 19(19). https://doi.org/10.3390/ijerph191912495

Cubeles-Juberias, E., Herrero, L., & Romero, M. del M. (2024). Effects of intermittent fasting on metabolism, cognitive function, and aging: a review of human and animal studies. Revista de La Sociedad Española de Cirugía de Obesidad y Metabólica y de La Sociedad Española Para El Estudio de La Obesidad. https://doi.org/10.53435/funj.00924

de Cabo, R., & Mattson, M. P. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. New England Journal of Medicine, 381(26), 2541–2551. https://doi.org/10.1056/nejmra1905136

Diab, R., Dimachkie, L., Zein, O., Dakroub, A., & Eid, A. H. (2024). Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health. Cell Biochemistry and Biophysics, 1583–1597. https://doi.org/10.1007/s12013-024-01314-9

Dong, H., Wang, S., Hu, C., Wang, M., Zhou, T., & Zhou, Y. (2024). Neuroprotective Effects of Intermittent Fasting in the Aging Brain. Annals of Nutrition and Metabolism, 80(4), 175–185. https://doi.org/10.1159/000538782

Funayama, M., Nishioka, K., Li, Y., & Hattori, N. (2023). Molecular genetics of Parkinson’s disease: Contributions and global trends. Journal of Human Genetics, 68(3), 125–130. https://doi.org/10.1038/s10038-022-01058-5

Gadhave, D. G., Sugandhi, V. V., Jha, S. K., Nangare, S. N., Gupta, G., Singh, S. K., Dua, K., Cho, H., Hansbro, P. M., & Paudel, K. R. (2024). Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance. Ageing Research Reviews, 99(May), 102357. https://doi.org/10.1016/j.arr.2024.102357

Gatto, E. M., Rojas, N. G., Persi, G., Etcheverry, J. L., Cesarini, M. E., & Perandones, C. (2020). Huntington disease: Advances in the understanding of its mechanisms. Clinical Parkinsonism and Related Disorders, 3, 100056. https://doi.org/10.1016/j.prdoa.2020.100056

Giri, P. M., Banerjee, A., Ghosal, A., & Layek, B. (2024). Neuroinflammation in Neurodegenerative Disorders: Current Knowledge and Therapeutic Implications. International Journal of Molecular Sciences, 25(7). https://doi.org/10.3390/ijms25073995

Gonzalez Rojas, N., Cesarini, M. E., Peker, G., Da Prat, G. A., Etcheverry, J. L., & Gatto, E. M. (2022). Review of Huntington’s Disease: From Basics to Advances in Diagnosis and Treatment. Journal of Neurology Research, 12(3), 93–113. https://doi.org/10.14740/jnr721

Jeevitha, M., Shanmuga Sundhram, R., & Sambath Kumar, R. (2024). Exploring the Neuroprotective Effects of Intermittent Fasting: A Comprehensive Review on its Impact on Neurological Diseases. Journal of Drug Delivery and Therapeutics, 14(3), 174–178. https://doi.org/10.22270/jddt.v14i3.6486

Kamboh, M. I. (2003). Genetics of Alzheimer’s Disease. Handbook of Medical Psychiatry, 23(4), 521–536. https://doi.org/10.3109/9780203912485-40

Lamptey, R. N. L., Chaulagain, B., Trivedi, R., Gothwal, A., Layek, B., & Singh, J. (2022). A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics. International Journal of Molecular Sciences, 23(3). https://doi.org/10.3390/ijms23031851

Lesage, S., & Trinh, J. (2023). Special Issue “Parkinson’s Disease: Genetics and Pathogenesis.” Genes, 14(3), 6–9. https://doi.org/10.3390/genes14030737

Mulas, A., Cienfuegos, S., Ezpeleta, M., Lin, S., Pavlou, V., & Varady, K. A. (2023). Effect of intermittent fasting on circulating inflammatory markers in obesity: A review of human trials. Frontiers in Nutrition, 10(April). https://doi.org/10.3389/fnut.2023.1146924

Muley, V. Y. (2023). Editorial: Gene expression: epigenetic and transcriptional regulation in neurodegenerative diseases and ageing. Frontiers in Neuroscience, 17. https://doi.org/10.3389/fnins.2023.1342890

Phillips, M. C. L. (2019). Fasting as a therapy in neurological disease. Nutrients, 11(10). https://doi.org/10.3390/nu11102501

Popa-Wagner, A., Dumitrascu, D., Capitanescu, B., Petcu, E., Surugiu, R., Fang, W. H., & Dumbrava, D. A. (2020). Dietary habits, lifestyle factors and neurodegenerative diseases. Neural Regeneration Research, 15(3), 394–400. https://doi.org/10.4103/1673-5374.266045

Shashikant, K., Sanjana, M., Gayatri, K., & Rakhi, G. (2024). Navigating Neurodegenerative Disorders: A Comprehensive Review of Current and Emerging Therapies for Neurodegenerative Disorders. Journal of Neuroscience and Neurological Disorders, 8(1), 033–046. https://doi.org/10.29328/journal.jnnd.1001095

Su, W. M., Gu, X. J., Duan, Q. Q., Jiang, Z., Gao, X., Shang, H. F., & Chen, Y. P. (2022). Genetic factors for survival in amyotrophic lateral sclerosis: an integrated approach combining a systematic review, pairwise and network meta-analysis. BMC Medicine, 20(1), 1–15. https://doi.org/10.1186/s12916-022-02411-3

Turana, Y., Shen, R., Nathaniel, M., Chia, Y. C., Li, Y., & Kario, K. (2022). Neurodegenerative diseases and blood pressure variability: A comprehensive review from HOPE Asia. Journal of Clinical Hypertension, 24(9), 1204–1217. https://doi.org/10.1111/jch.14559

Wang, H., Guan, L. P., & Deng, M. (2023). Recent progress of the genetics of amyotrophic lateral sclerosis and challenges of gene therapy. Frontiers in Neuroscience, 17(May), 1–12. https://doi.org/10.3389/fnins.2023.1170996

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